Indium - mediated Allylation of α - Imino Esters in Aqueous Media

Synthesis of a Phosphonate Analog of Sialic Acid (NeuSAc) Using Indium-Mediated Allylation of Unprotected Carbohydrates in Aqueous Media

Fluorous tagging: an enabling isolation technique for indium-mediated allylation reactions in water.

An efficient method was developed to allylate aldehydes using an aqueous indium-mediated allylation reaction with fluorous-tagged allyl halides, and to directly purify the products by fluorous solid phase extraction (F-SPE).

Radical allylations by reaction of azides with allylindium dichloride.

Allylindium dichloride is an effective reagent for carrying out photolytically initiated radical allylation reactions, as also proved by EPR experiments. In the presence of suitable azides that can give rise to electrophilic radicals, a homolytic chain reaction occurs with formation of allylated compounds. With delta-azido esters and chlorides generation of primary indiumaminyl radicals is foll...

Synthesis of a Phosphonate Analog of Sialic Acid (Neu5Ac) Using Indium-Mediated Allylation of Unprotected Carbohydrates in Aqueous Media

Sialic acid (Neu5Ac, 1), a constituent of sialoglycoproteins1 and gangliosides,2 mediates a number of intercellular and cell-virion recognition events.3 Analogs of sialic acid are interesting as potential inhibitors for medicinally important target proteins, such as neuraminidase of the influenza virus.4 The syntheses of sialic acid and its analogs have been the subject of extensive research.5 ...

Indium mediated allylation in peptide and protein functionalization.

Indium-mediated allylation has been used in the site-selective functionalization of N-terminal aldehydes of peptides and proteins. This is the first demonstration of indium-mediated C-C bond formation in protein labelling studies under mild and environmentally friendly conditions.